Unchained Labs

Labs Technology & Capabilities

Unchained Labs develops next-generation instrumentation and automation tools tailored for biologics, gene therapy, and nanoparticle research. Their technology combines precision measurement (e.g. UV/Vis spectroscopy, fluorescence, static & dynamic light scattering, microfluidics, Raman / LIBS, automation) with software-driven workflows to deliver fast, sample-efficient, multiplexed results. Their goal is to “uncage” researchers from cumbersome, low-throughput tools and enable higher throughput, lower sample consumption, and integrated insights.

Product / Instrument Ranges

Product / System	Purpose / Functionality
Uncle	All-in-one protein stability screening combining fluorescence, static light scattering (SLS), and dynamic light scattering (DLS) for thermal melting, aggregation, sizing, and refolding analysis.
Aunty	Fastest and highest-throughput protein stability characterization platform — reads a full 96-well plate per minute using fluorescence, SLS, and DLS for detailed melting and aggregation profiling.
Stunner	Combines UV/Vis quantification with DLS/SLS sizing on the same 2 µL sample; measures concentration, size, aggregation, titer, and RNA payload for proteins, viral vectors, and lipid nanoparticles.
Lunatic	Next-generation UV/Vis spectrophotometer for quantifying proteins, DNA, and RNA in 2 µL volumes; handles up to 96 samples in 10 minutes with no dilution.
Honeybun	Rapid two-in-one microfluidic viscometer and rheometer measuring viscosities from 0.5–150 cP using only microliters of sample — ideal for biologics formulations.
Unagi	Fully hands-free benchtop buffer exchange solution automating ultrafiltration/diafiltration (UF/DF) for proteins, gene therapy vectors, and nanoparticles; minimizes manual handling time.
Big Tuna	High-throughput automated buffer exchange and concentration platform for proteins, LNPs, and viral vectors — less than 15 minutes setup time for parallel UF/DF operations.
Sunscreen	Rapid LNP formulation screener producing 96 unique lipid nanoparticle formulations in under 6 hours; explores lipid ratios, payload ratios, and flow rates for formulation optimization.
Sunshine	LNP process development system for optimizing flow rate, mixing, and dilution; supports continuous mode production of tens of liters per day for scale-up.
Sunbather	GMP-ready LNP production system enabling seamless tech transfer with identical flow path and process parameters as Sunscreen/Sunshine; includes replaceable flow path and documentation.
Leprechaun	Lentivirus and exosome characterization tool measuring titer, structure, and RNA payload even in crude samples; provides particle size, phenotype, and concentration.
Junior / Big Kahuna	Modular automation platforms integrating liquid handling, formulation, and analytical workflows — scalable from benchtop R&D to full process automation.