WelPacker Dynamic Axial Compression (DAC) Columns
High-Performance Packing • Industrial Durability • Scalable for Every Purification Need
Welch DAC Columns are engineered for high-efficiency packing and large-scale chromatographic purification. Using advanced Dynamic Axial Compression (DAC) technology, these columns maintain constant, uniform compression on the packing bed—improving stability, extending media lifetime, and delivering superior reproducibility from batch to batch.
Whether purifying peptides, oligonucleotides, biopharmaceuticals, natural products, or chemical intermediates, Welch DAC Columns provide reliable, scalable solutions from 50 mm to 2000 mm internal diameter.
Dynamic Axial Compression Column Technology
DAC technology continuously applies axial pressure on the packed bed using a hydraulic or mechanical compression system. This ensures:
- Stable and tightly packed media without channeling
- Better separation efficiency, especially for large-scale purification
- Reduced bed collapse even under high-pressure conditions
- Improved reproducibility over multiple packing cycles
This makes DAC columns the preferred choice for GMP-scale purification in pharma and biotech.
Advanced Column Design
H-Tree Distribution Plate
- Ensures uniform flow distribution across the entire column bed
- Minimizes turbulence and dead zones
- Significantly enhances separation efficiency and peak symmetry
Optimized Mechanical Structure
- Precision-machined stainless steel for long-term durability
- Smooth internal polishing for maximum flow and minimum retention
High-strength locking and compression system for stable operation
Welch DAC Column Specifications (50mm – 2000mm)
Category | Specification |
Available Column IDs | 50 mm – 2000 mm |
Design Pressure | ≤ 10 MPa |
Inner Wall Roughness | ≤ 0.2 µm |
Sieve Plates (Apertures) | 2 µm / 3 µm / 5 µm |
Wetted Materials | 316L Stainless Steel, PTFE, PEEK |
Distribution System | H-Tree Flow Distribution |
Compression Method | Dynamic Axial Compression (Hydraulic / Mechanical) |
Overpressure Protection | Integrated Safety Valve |
Key Features & Advantages
✔ Uniform Packing & High Efficiency
Consistent axial pressure ensures a stable and uniform packing bed, delivering sharper peaks and reproducible purification profiles
✔ Scalable for All Production Needs
Available in a full range of diameters from small pilot-scale (50 mm) to industrial production-scale (2000 mm).
✔ Superior Mechanical Precision
Polished internal surfaces (≤ 0.2 μm Ra) improve flow dynamics and reduce carryover.
✔ Compatible with All Media Types
Silica, polymeric, HILIC, C18, ion-exchange, mixed-mode, and custom packing materials.
✔ Safe & Reliable Operation
Overpressure protection and robust design make it suitable for long-term operation in GMP environments.
✔ Easy Maintenance & Replicable Packing
Quick disassembly structure reduces downtime and simplifies re-packing.
Applications
- Peptide & oligonucleotide purification
- Biopharmaceutical intermediates
- Natural product & herbal extraction
- Organic chemical purification
- Large-scale API production
- Process-scale chiral & achiral separations